Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/93148
DC FieldValueLanguage
dc.contributor.authorAlves, Américo J. S.-
dc.contributor.authorMelo, Teresa M. V. D. Pinho e-
dc.date.accessioned2021-02-17T12:30:13Z-
dc.date.available2021-02-17T12:30:13Z-
dc.date.issued2020-
dc.identifier.issn1434-193Xpt
dc.identifier.issn1099-0690pt
dc.identifier.urihttp://hdl.handle.net/10316/93148-
dc.description.abstractThe synthesis of a library of 6‐alkylidene‐β‐lactams, derived from 6‐aminopenicillanic acid is reported. The 1,3‐dipolar cycloaddition of these 6‐alkylidenepenicillanates with nitrones was explored as an approach to synthesize novel chiral spiroisoxazolidine‐β‐lactams. The reported methodology, which involves the generation of three new consecutive stereogenic centers, proved to be regio‐ and stereoselective, leading to novel chiral spiroisoxazolidine‐penicillanates efficiently.pt
dc.language.isoengpt
dc.publisherWileypt
dc.relationUIDP/00313/2020pt
dc.relationUIDB/00313/2020pt
dc.relationSFRH/BD/128910/2017pt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectSpiro‐β‐lactamspt
dc.subjectIsoxazolidinespt
dc.subjectPenicillanatespt
dc.subjectNitronespt
dc.subject1,3‐Dipolar cycloadditionpt
dc.titleSynthesis of Novel Chiral Spiroisoxazolidine‐β‐Lactams from 6‐Alkylidenepenicillanates: A 1,3‐Dipolar Cycloaddition Approachpt
dc.typearticle-
degois.publication.firstPage6259pt
degois.publication.lastPage6269pt
degois.publication.issue39pt
degois.publication.titleEuropean Journal of Organic Chemistrypt
dc.relation.publisherversionhttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202001085pt
dc.peerreviewedyespt
dc.identifier.doi10.1002/ejoc.202001085pt
degois.publication.volume2020pt
dc.date.embargo2020-12-31*
uc.date.periodoEmbargo365pt
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0003-3256-4954-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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