Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/93148
Title: Synthesis of Novel Chiral Spiroisoxazolidine‐β‐Lactams from 6‐Alkylidenepenicillanates: A 1,3‐Dipolar Cycloaddition Approach
Authors: Alves, Américo J. S.
Melo, Teresa M. V. D. Pinho e 
Keywords: Spiro‐β‐lactams; Isoxazolidines; Penicillanates; Nitrones; 1,3‐Dipolar cycloaddition
Issue Date: 2020
Publisher: Wiley
Project: UIDP/00313/2020 
UIDB/00313/2020 
SFRH/BD/128910/2017 
Serial title, monograph or event: European Journal of Organic Chemistry
Volume: 2020
Issue: 39
Abstract: The synthesis of a library of 6‐alkylidene‐β‐lactams, derived from 6‐aminopenicillanic acid is reported. The 1,3‐dipolar cycloaddition of these 6‐alkylidenepenicillanates with nitrones was explored as an approach to synthesize novel chiral spiroisoxazolidine‐β‐lactams. The reported methodology, which involves the generation of three new consecutive stereogenic centers, proved to be regio‐ and stereoselective, leading to novel chiral spiroisoxazolidine‐penicillanates efficiently.
URI: http://hdl.handle.net/10316/93148
ISSN: 1434-193X
1099-0690
DOI: 10.1002/ejoc.202001085
Rights: embargoedAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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