Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/93144
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dc.contributor.authorBrandão, Pedro-
dc.contributor.authorMarques, Carolina-
dc.contributor.authorBurke, Anthony J.-
dc.contributor.authorPineiro, Marta-
dc.date.accessioned2021-02-17T11:42:45Z-
dc.date.available2021-02-17T11:42:45Z-
dc.date.issued2021-02-05-
dc.identifier.issn02235234pt
dc.identifier.urihttp://hdl.handle.net/10316/93144-
dc.description.abstractOxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning the preparation of oxindole derivatives using isatin-based multicomponent reactions (MCRs) constitute a great advance in generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring the synthetic pathways and biological activities described for these compounds, namely antitumor, antibacterial, antifungal, antiparasitic, antiviral, antioxidant, anti-inflammatory and central nervous system (CNS) pathologies. To add new depth to this work, we used a well-established web-based free tool (SwissADME) to evaluate the most promising scaffolds in what concerns their druglike properties, namely by evaluating their compliance with some of the most valuable rules applied by medicinal chemists in both academia and industrial settings (Lipinski, Ghose, Veber, Egan, Muegge). The aim of this review is to endorse isatin-based MCRs as a valuable synthetic approach to attain new hit compounds bearing the oxindole privileged structure, while critically exploring these scaffolds' druglike properties.pt
dc.language.isoengpt
dc.publisherElsevier Massonpt
dc.relationPD/BD/128490/2017pt
dc.relationUIDB/00313/2020pt
dc.relationUIDB/50006/2020pt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectBioactive compoundspt
dc.subjectIsatinpt
dc.subjectMulticomponent reactionspt
dc.subjectOxindolept
dc.titleThe application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike moleculespt
dc.typearticle-
degois.publication.firstPage113102pt
degois.publication.titleEuropean Journal of Medicinal Chemistrypt
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0223523420310746pt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.ejmech.2020.113102pt
degois.publication.volume211pt
dc.date.embargo2023-02-05*
uc.date.periodoEmbargo730pt
item.grantfulltextembargo_20230205-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-7460-3758-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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