Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/92473
Title: Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Authors: Ferreira, Raquel
Napoli, Joseph
Enver, Tariq
Bernardino, Liliana 
Ferreira, Lino 
Issue Date: 26-Aug-2020
Publisher: Nature
Project: POCI-01-0145-FEDER-016390 (acronym: CANCEL STEM) 
2IQBIONEURO (reference: 0624_2IQBIONEURO_6_E) 
UID/Multi/00709/2013 
info:eu-repo/grantAgreement/EC/H2020/669088/EU 
POCI-01-0145- 619 FEDER-029414 (acronym: LIghtBRARY) 
NEUROATLANTIC (reference: EAPA_791/2018) 
info:eu-repo/grantAgreement/RCUK/Innovate UK/102103/GB/Veterinary clinical data surveillance 
SFRH/BPD/102103/2014 624 (UID/Multi/00709/2013), “Programa Operacional do Centro, Centro 2020” through the funding of 625 the ICON project (Interdisciplinary Challenges On Neurodegeneration; CENTRO-01-0145- 626 FEDER-000013), EXPL/BIM-MED/0822/2013 (LB), (SFRH/BPD/94228/2013, IF/00178/2015) 627 (RF), 
SFRH/BPD/94228/2013, IF/00178/2015 
info:eu-repo/grantAgreement/RCUK/Innovate UK/120146/GB/ICON 
CENTRO-01-0145- 626 FEDER-000013 
EXPL/BIM-MED/0822/2013 
Serial title, monograph or event: Nature Communications
Volume: 11
Abstract: Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of some of the physicochemical limitations of retinoids, the development of drug delivery systems offers several advantages for clinical translation of retinoid-based therapies, including improved solubilization, prolonged circulation, reduced toxicity, sustained release, and improved efficacy. In this Review, we discuss advances in preclinical and clinical tests regarding retinoid formulations, specifically the ones based in natural retinoids, evaluated in the context of regenerative medicine, brain, cancer, skin, and immune diseases. Advantages and limitations of retinoid formulations, as well as prospects to push the field forward, will be presented.
URI: http://hdl.handle.net/10316/92473
DOI: 10.1038/s41467-020-18042-2
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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