Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/91151
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dc.contributor.authorPires, Ana Salomé-
dc.contributor.authorBatista, João-
dc.contributor.authorMurtinho, Dina-
dc.contributor.authorNogueira, Célia-
dc.contributor.authorKaramysheva, Anna-
dc.contributor.authorRamos, Maria Luísa-
dc.contributor.authorMilne, Bruce-
dc.contributor.authorTavares, Nuno Tiago-
dc.contributor.authorGonçalves, José-
dc.contributor.authorGonçalves, Ana Cristina-
dc.contributor.authorAbrantes, Ana Margarida-
dc.contributor.authorSoares, Rui-
dc.contributor.authorGonçalves, Teresa-
dc.contributor.authorBotelho, Maria Filomena-
dc.contributor.authorSilva Serra, Maria Elisa-
dc.date.accessioned2020-10-10T11:21:46Z-
dc.date.available2020-10-10T11:21:46Z-
dc.date.issued2020-02-03-
dc.identifier.issn0268-2605pt
dc.identifier.issn1099-0739pt
dc.identifier.urihttp://hdl.handle.net/10316/91151-
dc.description.abstractPlatinum metal complexes are the most common chemotherapeutics currently used in cancer treatment. However, the frequent adverse effects, as well as acquired resistance by tumor cells, urge the development of effective alternatives. In the recent past, copper complexes with Schiff base ligands have emerged as good alternatives, showing interesting results. Accordingly, and in continuation of previous studies in this area, three new camphoric acid‐derived halogenated salen ligands and their corresponding Cu (II) complexes were synthesized and their antitumor activity was evaluated in order to determine the influence of the type and number of halogens present (Br, Cl). The in vitro cytotoxic activity was screened against colorectal WiDr and LS1034 and against breast MCF‐7 and HCC1806 cancer cell lines. The results proved the halogenated complexes to be very efficient, the tetrachlorinated Cu (II) complex being the most promising, presenting IC50 of 0.63–1.09 μM for the cell lines studied. The complex also shows selectivity to colorectal cancer cells compared to non‐tumor colon cells. It is worth highlighting that the tetrachlorinated Cu (II) complex, our most efficient complex, shows a significantly more powerful antitumor effect than the reference drugs currently used in conventional chemotherapy. The halogenated salen and corresponding complexes were also screened for their antimicrobial activity against four bacterial species‐Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa‐and four fungal species‐Candida albicans, Candida glabrata, Aspergillus fumigatus and Alternaria alternata. The compounds were found to exhibit moderate to strong antibacterial activity against the bacterial strains studied. NMR studies and theoretical calculations provided some insight into the structure of the ligands and copper complexes. Considering the results presented herein, our work validates the potential use of copper‐based chemotherapeutics as alternatives for cancer treatment.pt
dc.language.isoengpt
dc.publisherWileypt
dc.relationinfo:eu-repo/grantAgreement/CENTRO-01-0145-FEDER-000014/PTpt
dc.relationinfo:eu-repo/grantAgreement/POCI‐01‐0145‐FEDER-007440/PTpt
dc.relationinfo:eu-repo/grantAgreement/REEQ/481/QUI/2006pt
dc.relationinfo:eu-repo/grantAgreement/RECI/QEQ‐QFI/0168/2012pt
dc.relationinfo:eu-repo/grantAgreement/FCT/04539/2013/PTpt
dc.relationinfo:eu-repo/grantAgreement/FCT/04539/2019pt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectCopper salenspt
dc.subjectCytotoxic activitypt
dc.subjectAntimicrobial activitypt
dc.subjectNMR studiespt
dc.subjectLigand geometry optimizationpt
dc.titleSynthesis, Characterization and Evaluation of the Antibacterial and Antitumor Activity of HalogenatedSalen Copper (II) Complexes derived from Camphoric Acidpt
dc.typearticle-
degois.publication.firstPagee5569pt
degois.publication.issue5pt
degois.publication.titleApplied Organometallic Chemistrypt
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.5569pt
dc.peerreviewedyespt
dc.identifier.doi10.1002/aoc.5569pt
degois.publication.volume34pt
dc.date.embargo2021-02-02*
uc.date.periodoEmbargo365pt
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-1391-9855-
crisitem.author.orcid0000-0003-3230-8045-
crisitem.author.orcid0000-0002-5522-4808-
crisitem.author.orcid0000-0001-9347-0535-
crisitem.author.orcid0000-0001-7202-1650-
crisitem.author.orcid0000-0002-4562-7072-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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