Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/90790
DC FieldValueLanguage
dc.contributor.authorVinagreiro, Carolina dos Santos-
dc.contributor.authorZangirolami, Amanda-
dc.contributor.authorSchaberle, Fábio António-
dc.contributor.authorNunes, Sandra Cristina da Cruz-
dc.contributor.authorBlanco, Kate C-
dc.contributor.authorInada, Natalia M.-
dc.contributor.authorSilva, Gabriela Jorge da-
dc.contributor.authorPais, Alberto A. C. C.-
dc.contributor.authorBagnato, Vanderlei S-
dc.contributor.authorMoreira, Luís Guilherme da Silva Arnaut-
dc.contributor.authorPereira, Mariette M.-
dc.date.accessioned2020-09-07T13:44:09Z-
dc.date.available2020-09-07T13:44:09Z-
dc.date.issued2020-
dc.identifier.issn2373-8227pt
dc.identifier.issn2373-8227pt
dc.identifier.urihttp://hdl.handle.net/10316/90790-
dc.description.abstractGram-negative bacteria and bacteria in biofilms are very difficult to eradicate and are the most antibiotic-resistant bacteria. Therapeutic alternatives less susceptible to mechanisms of resistance are urgently needed to respond to an alarming increase of resistant nosocomial infections. Antibacterial photodynamic inactivation (PDI) generates oxidative stress that triggers multiple cell death mechanisms that are more difficult to counteract by bacteria. We explore PDI of multidrug-resistant bacterial strains collected from patients and show how positive charge distribution in the photosensitizer drug impacts the efficacy of inactivation. We demonstrate the relevance of size for drug diffusion in biofilms. The designed meso-imidazolyl porphyrins of small size with positive charges surrounding the macrocycle enabled the inactivation of bacteria in biofilms by 6.9 log units at 5 nM photosensitizer concentration and 5 J cm-2, which offers new opportunities to treat biofilm infections.pt
dc.language.isoengpt
dc.publisherACS Publicationspt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectAntibioticspt
dc.subjectBiofilmspt
dc.subjectMultiresistant bacteriapt
dc.subjectPhotodynamic inactivationpt
dc.subjectPorphyrinoidspt
dc.titleAntibacterial Photodynamic Inactivation of Antibiotic-Resistant Bacteria and Biofilms with Nanomolar Photosensitizer Concentrationspt
dc.typearticle-
degois.publication.firstPage1517pt
degois.publication.lastPage1526pt
degois.publication.issue6pt
degois.publication.titleInfectious Diseasespt
dc.relation.publisherversionhttps://pubs.acs.org/doi/abs/10.1021/acsinfecdis.9b00379pt
dc.peerreviewedyespt
dc.identifier.doi10.1021/acsinfecdis.9b00379pt
degois.publication.volume6pt
dc.date.embargo2020-12-31*
uc.date.periodoEmbargo365pt
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-9339-7259-
crisitem.author.orcid0000-0002-3060-5719-
crisitem.author.orcid0000-0002-7479-8540-
crisitem.author.orcid0000-0002-6725-6460-
crisitem.author.orcid0000-0002-3223-4819-
crisitem.author.orcid0000-0003-4958-7677-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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