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Title: HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population
Authors: Jacq, Laurent 
Teixeira, Vitor 
Garnier, Sophie 
Michou, Laëtitia 
Dieudé, Philippe 
Rocha, Dominique 
Pierlot, Céline 
Lemaire, Isabelle 
Quillet, Patrick 
Hilliquin, Pascal 
Mbarek, Hamdi 
Petit-Teixeira, Elisabeth 
Cornélis, François 
Issue Date: 2007
Citation: Journal of Human Genetics. 52:12 (2007) 1036-1039
Abstract: Abstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three single nucleotide polymorphisms (SNPs) were studied in 100 RA trio families, and 100 other families were used for replication. Genetic analyses were performed by comparing allelic frequencies, by applying the transmission disequilibrium test, and by assessing the genotype relative risk. We observed a significant RA association for the C/C genotype of rs2340690 in the first sample. However, this association was not confirmed when the second sample was added. The two other SNPs and the haplotype analysis did not give any significant results. We conclude that HSPD1 is not a major RA susceptibility gene in the French Caucasian population.
DOI: 10.1007/s10038-007-0201-y
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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