Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8447
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dc.contributor.authorMiddleton, Frank A.-
dc.contributor.authorPato, Carlos N.-
dc.contributor.authorGentile, Karen L.-
dc.contributor.authorMcGann, Lindsay-
dc.contributor.authorBrown, Andrea M.-
dc.contributor.authorTrauzzi, Marco-
dc.contributor.authorDiab, Heba-
dc.contributor.authorMorley, Christopher P.-
dc.contributor.authorMedeiros, Helena-
dc.contributor.authorMacedo, Antonio-
dc.contributor.authorAzevedo, M. Helena-
dc.contributor.authorPato, Michele T.-
dc.date.accessioned2009-02-09T14:54:25Z-
dc.date.available2009-02-09T14:54:25Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 136B:1 (2005) 12-25en_US
dc.identifier.urihttp://hdl.handle.net/10316/8447-
dc.description.abstractWe performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorder). At the single gene level, we obtained lists of the transcripts with the most significant changes in expression and from these lists determined those with the highest degree of predictive power for classifying subjects according to diagnosis in these samples. At the gene group level, we comprehensively analyzed pairwise expression changes of more than 4,000 functional groups and cytogenetic locations, and present a novel method of displaying these data that we term ldquocytogenomicrdquo mapping. Verification of selected changes in expression was performed using quantitative real-time RT-PCR. Our results provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders. © 2005 Wiley-Liss, Inc.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleGene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approachesen_US
dc.typearticleen_US
dc.identifier.doi10.1002/ajmg.b.30171en_US
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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