Please use this identifier to cite or link to this item:
Title: Probing pseudopolymorphic transitions in pharmaceutical solids using Raman spectroscopy: Hydration and dehydration of theophylline
Authors: Amado, Ana M. 
Nolasco, Mariela M. 
Ribeiro-Claro, Paulo J. A. 
Issue Date: 2007
Citation: Journal of Pharmaceutical Sciences. 96:5 (2007) 1366-1379
Abstract: Theophylline is known to undergo vapor phase induced hydrate-anhydrate pseudopolymorphic transformations, which can affect its bioavailability. In this work, the kinetics of the pseudopolymorphic transitions of theophylline crystals in different storage conditions is studied using a vibrational spectroscopic technique. While the hydration is a single-step process with a half-life time of ca. 5 h, the dehydration occurs through a two-step mechanism. In addition, the phase stability of hydrate-anhydrate systems in different relative humidity (RH) conditions was probed. The critical RH for anhydrous teophylline was found to be at ca. 79%, while the critical RH for dehydration is ca. 30%. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96: 1366-1379, 2007
DOI: 10.1002/jps.20923
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
obra.pdf243.35 kBAdobe PDFView/Open
Show full item record


checked on Nov 8, 2019

Page view(s)

checked on Nov 19, 2019


checked on Nov 19, 2019

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.