Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/80903
Title: Aging Hallmarks: The Benefits of Physical Exercise
Authors: Rebelo-Marques, Alexandre 
De Sousa Lages, Adriana 
Andrade, Renato 
Ribeiro, Carlos Fontes 
Mota-Pinto, Anabela 
Carrilho, Francisco 
Espregueira-Mendes, João 
Keywords: Aging/Envelhecimento; Exercício Físico/Physical Exercise
Issue Date: 2018
Publisher: Frontiers
Abstract: World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
URI: http://hdl.handle.net/10316/80903
DOI: 10.3389/fendo.2018.00258
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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