Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/80883
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dc.contributor.authorLopes, Ana C-
dc.contributor.authorCova, Tânia F G G-
dc.contributor.authorPais, Alberto A C C-
dc.contributor.authorPereira, Jorge L G F S C-
dc.contributor.authorColaço, Bruno-
dc.contributor.authorCabrita, António M S-
dc.date.accessioned2018-09-24T15:07:17Z-
dc.date.available2018-09-24T15:07:17Z-
dc.date.issued2014-01-
dc.identifier.issn1618-1433pt
dc.identifier.urihttp://hdl.handle.net/10316/80883-
dc.description.abstractThis work aims at characterizing rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) and the respective malignancy potential, commonly graded with histopathology features grouped by intensity levels. Tumors were described over fourteen multiple ranged microscopic parameters and a comprehensive characterization of the histological patterns and their relation with tumor grade was carried out by principal component analysis (PCA). The number of histological patterns present on a tumor tends to correlate with malignant features. High grade tumors are characterized by the presence of several structural patterns, with cribriform prevalence and necrosis. The cribriform pattern correlates with grading, i.e., tumors having a higher predominance of the cribriform pattern are likely to be more malignant. The findings may represent a benchmark for similar characterization studies in other models.pt
dc.language.isoporpt
dc.rightsopenAccesspt
dc.titleImproving discrimination in the grading of rat mammary tumors using two-dimensional mapping of histopathological observationspt
dc.typearticle-
degois.publication.firstPage73-80pt
degois.publication.lastPage80pt
degois.publication.issue1pt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.etp.2013.09.001pt
degois.publication.volume66pt
dc.date.embargo2014-01-01*
dc.date.periodoembargo0pt
dc.identifier.pmid24168877-
item.fulltextCom Texto completo-
item.languageiso639-1pt-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Medicina, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.orcid0000-0002-2840-6091-
crisitem.author.orcid0000-0002-6725-6460-
crisitem.author.orcid0000-0002-8633-3716-
crisitem.author.orcid0000-0001-5165-5849-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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