Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8070
Title: Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples
Authors: Manco, Licínio 
Machado, Patrícia 
Lopes, Dinora 
Nogueira, Fátima 
Rosário, Virgílio E. Do 
Alonso, Pedro L. 
Varandas, Luís 
Trovoada, Maria De Jesus 
Amorim, António 
Arez, Ana Paula 
Issue Date: 2009
Publisher: Wiley-Liss
Citation: American Journal of Human Biology. 21:1 (2009) 118-120
Abstract: Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem
URI: http://hdl.handle.net/10316/8070
DOI: 10.1002/ajhb.20819
Rights: openAccess
Appears in Collections:I&D CIAS - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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