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Title: Spectroscopic and electrochemical studies of cocaine–opioid interactions
Authors: Garrido, Jorge 
Marques, M. Paula M. 
Silva, Artur 
Macedo, Tice 
Brett, Ana Oliveira 
Borges, Fernanda 
Keywords: Analgesics, Opioid; Binding Sites; Cocaine; Drug Interactions; Electrochemistry; Morphine; Quantum Theory; Solutions; Spectrum Analysis
Issue Date: 2007
Citation: Analytical and Bioanalytical Chemistry. 388:8 (2007) 1799-1808
Serial title, monograph or event: Analytical and Bioanalytical Chemistry
Volume: 388
Issue: 8
Abstract: Abstract The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine–opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug–drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine–morphine mixture (C–MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine’s methyl ester group. NMR studies conducted simultaneously also revealed C–MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine–morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine–heroin mixture. Figure "Schematic representation of the proposed model for cocaine:morphine salt interaction"
DOI: 10.1007/s00216-007-1375-z
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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