Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5447
DC FieldValueLanguage
dc.contributor.authorPalmeira, C. M.-
dc.contributor.authorRana, M. I.-
dc.contributor.authorFrederick, C. B.-
dc.contributor.authorWallace, K. B.-
dc.date.accessioned2008-09-01T15:42:26Z-
dc.date.available2008-09-01T15:42:26Z-
dc.date.issued2000en_US
dc.identifier.citationBiochemical and Biophysical Research Communications. 272:2 (2000) 431-435en_US
dc.identifier.urihttp://hdl.handle.net/10316/5447-
dc.description.abstractWe recently reported that acrylic acid (AA) induces the MPT in vitro, which we suggested might be a critical event in the acute inflammatory and hyperplastic response of the olfactory epithelium. The purpose of the present investigation was to determine if induction of the MPT is a general response to short-chain carboxylic acids or if there are critical physical chemical parameters for this response. Freshly isolated rat liver mitochondria were incubated in the presence of varying concentrations of selected carboxylic acids. All of the acids that we tested caused a concentration-dependent induction of the MPT, which was blocked by cyclosporine A. Although the C4 carboxylic acids were slightly more potent than the C5 acids, there was no correlation with the degree of saturation, the octanol/water coefficient (log P), or the dissociation constant (pKa) of the acids that we tested. We conclude that induction of the MPT in vitro is a general response to short-chain carboxylic acids having a pKa of 4 to 5.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6WBK-45FC9R7-T/1/dc27a6024b50dcc55a92198672d5618aen_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectliver mitochondria; permeability transition; carboxylic acids; cyclosporine Aen_US
dc.titleInduction of the Mitochondrial Permeability Transition in Vitro by Short-Chain Carboxylic Acidsen_US
dc.typearticleen_US
dc.identifier.doi10.1006/bbrc.2000.2797-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-2639-7697-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
file551759df141443b3824c8498c8d7e7ed.pdf70.88 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations

9
checked on Nov 17, 2022

WEB OF SCIENCETM
Citations 50

8
checked on Nov 15, 2022

Page view(s) 50

476
checked on Dec 5, 2022

Download(s) 50

482
checked on Dec 5, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.