Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5272
DC FieldValueLanguage
dc.contributor.authorNeves, M.-
dc.contributor.authorFausto, R.-
dc.date.accessioned2008-09-01T15:06:53Z-
dc.date.available2008-09-01T15:06:53Z-
dc.date.issued1999en_US
dc.identifier.citationNuclear Medicine and Biology. 26:1 (1999) 85-89en_US
dc.identifier.urihttp://hdl.handle.net/10316/5272-
dc.description.abstractThe structures of some Tc-biguanide complexes are predicted by molecular mechanics calculations. In addition, simulations of molecular interactions between the predicted equilibrium structures with water molecules or peptide chains are correlated with experimental data of partition coefficients and percentage of human protein binding, evaluated for the analogous 99mTc-biguanide complexes. These results suggest the value of computer-assisted design of new Tc-radiopharmaceuticals, and in particularly, stress the great interest of using molecular modelling to predict molecular properties that can be successfully correlated with results obtained by in vitro studies.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T9Y-3VH7RJ1-F/1/28c6254dbf87e9167c6d54b03225652cen_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectComputational chemistryen_US
dc.subjectMolecular modellingen_US
dc.subject99mTc-biguanide complexesen_US
dc.titlePrediction of 99mtc-biguanide complex structures and their interactions with biological molecules by molecular mechanics calculationsen_US
dc.typearticleen_US
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.orcid0000-0002-8264-6854-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
filebb968788adc040b2beea7c026c14f8ab.pdf483.25 kBAdobe PDFView/Open
Show simple item record

Page view(s)

167
checked on Mar 24, 2020

Download(s)

63
checked on Mar 24, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.