Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5117
DC FieldValueLanguage
dc.contributor.authorPeixoto, Francisco-
dc.contributor.authorVicente, Joaquim-
dc.contributor.authorMadeira, Vítor M. C.-
dc.date.accessioned2008-09-01T15:04:14Z-
dc.date.available2008-09-01T15:04:14Z-
dc.date.issued2004en_US
dc.identifier.citationToxicology in Vitro. 18:6 (2004) 733-739en_US
dc.identifier.urihttp://hdl.handle.net/10316/5117-
dc.description.abstractRat liver mitochondria are much more susceptible to protein oxidation induced by paraquat than plant mitochondria. The unsaturated index and the peroxidizability index are higher in rat than in potato tuber. The levels of superoxide dismutase and glutathione reductase are concurrent with the different sensitivities to paraquat, with higher activities in plant mitochondria. However, glutathione peroxidase and catalase activities are higher in rat mitochondria. Paraquat (10 mM) inhibited all the enzymatic activities; excluding catalase all the other activities were inhibited to a similar degree. The differential sensitivities of plant and animal mitochondria to paraquat correlate with fatty acid composition of mitochondrial lipids and a similar correlation was also established for some antioxidant enzymes. At the mitochondrial level, H2O2 is not a major factor of paraquat toxicity since rat liver mitochondria which exhibit higher activities of glutathione peroxidase and catalase are however more susceptible to paraquat.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TCP-4C47JVD-3/1/ef7e44af2ded145614d9b786098438ceen_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectParaquaten_US
dc.subjectMitochondriaen_US
dc.subjectHydrogen peroxideen_US
dc.subjectAntioxidante enzymesen_US
dc.subjectHerbicide toxicityen_US
dc.titleA comparative study of plant and animal mitochondria exposed to paraquat reveals that hydrogen peroxide is not related to the observed toxicityen_US
dc.typearticleen_US
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
Files in This Item:
File Description SizeFormat
fileac99818ab594434aa9adbbef3208e892.pdf285.35 kBAdobe PDFView/Open
Show simple item record

Page view(s)

268
checked on Sep 23, 2020

Download(s) 20

632
checked on Sep 23, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.