Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5000
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dc.contributor.authorSerra, A. C.-
dc.contributor.authorPineiro, M.-
dc.contributor.authorGonsalves, A. M. d'A. Rocha-
dc.contributor.authorAbrantes, M.-
dc.contributor.authorLaranjo, M.-
dc.contributor.authorSantos, A. C.-
dc.contributor.authorBotelho, M. F.-
dc.date.accessioned2008-09-01T15:02:12Z-
dc.date.available2008-09-01T15:02:12Z-
dc.date.issued2008en_US
dc.identifier.citationJournal of Photochemistry and Photobiology B: Biology. 92:1 (2008) 59-65en_US
dc.identifier.urihttp://hdl.handle.net/10316/5000-
dc.description.abstractBrominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TH0-4SCKRV7-2/1/f341bf72f1ad4338d46c1c71eadc64e3en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectHalogenated porphyrinsen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectHeavy atom effecten_US
dc.titleHalogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrinen_US
dc.typearticleen_US
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Medicina, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCentre for Mechanical Engineering-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCoimbra Chemistry Center-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0001-8664-2757-
crisitem.author.orcid0000-0002-7460-3758-
crisitem.author.orcid0000-0001-9987-7301-
crisitem.author.orcid0000-0001-7202-1650-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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