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Title: Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin
Authors: Serra, A. C. 
Pineiro, M. 
Gonsalves, A. M. d'A. Rocha 
Abrantes, M. 
Laranjo, M. 
Santos, A. C. 
Botelho, M. F. 
Keywords: Halogenated porphyrins; Photodynamic therapy; Heavy atom effect
Issue Date: 2008
Citation: Journal of Photochemistry and Photobiology B: Biology. 92:1 (2008) 59-65
Abstract: Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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