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Title: Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hippocampal [3H]GABA release
Authors: A. Cunha, Rodrigo 
Malva, João O. 
Ribeiro, J. A. 
Keywords: Kainate receptor; G protein; Protein kinase C; Hippocampus
Issue Date: 2000
Citation: FEBS Letters. 469:2-3 (2000) 159-162
Abstract: Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in synaptosomes pre-treated with pertussis toxin. Protein kinase C inhibition attenuated by 82% domoate-induced inhibition of GABA release whereas protein kinase C activation did not change kainate receptor binding. Thus, domoate inhibition of GABA release recruits Gi/Go proteins and a protein kinase C pathway.
DOI: 10.1016/S0014-5793(00)01272-2
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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