Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/47550
DC FieldValueLanguage
dc.contributor.authorPereira, Cláudia V.-
dc.contributor.authorMoreira, Ana C.-
dc.contributor.authorPereira, Susana P.-
dc.contributor.authorMachado, Nuno G.-
dc.contributor.authorCarvalho, Filipa S.-
dc.contributor.authorSardão, Vilma A.-
dc.contributor.authorOliveira, Paulo J.-
dc.date.accessioned2018-02-12T13:18:38Z-
dc.date.available2018-02-12T13:18:38Z-
dc.date.issued2009-01-
dc.identifier.urihttp://hdl.handle.net/10316/47550-
dc.description.abstractMitochondria are recognized as the producers of the majority of energy cells need for their normal activity. After the initial comprehension of how mitochondrial oxidative phosphorylation produces energy, mitochondrial research was not a priority for most cell biologists until novel mitochondrial functions were identified. In fact, it is now known that mitochondria are not only involved in cell calcium homeostasis, intermediate metabolism and free radical generation but are also a crucial crossroad for several cell death pathways. The notion that several clinically used drugs and other xenobiotics induce organ degeneration through damaging mitochondrial bioenergetics led to the use of the organelle as an effective and reliable bio-sensor to predict drug safety. Classic methods used to test the toxicity of a wide range of compounds on isolated mitochondrial fractions were later replaced by novel high-throughput methods to investigate the safety of a very large number of new molecules. Without surprise, the assessment of "mitochondrial safety" for new discovered molecules is of clear interest for pharmaceutical companies which can now select compounds lacking mitochondrial toxicity to undergo further trials, thus avoiding the possibility of later human toxicity due to mitochondrial liabilities.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnimalspor
dc.subjectBiosensing Techniquespor
dc.subjectDrug Designpor
dc.subjectHumanspor
dc.subjectMitochondriapor
dc.subjectOxidative Phosphorylationpor
dc.subjectToxicity Testspor
dc.subjectDrug-Related Side Effects and Adverse Reactionspor
dc.titleInvestigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?por
dc.typearticle-
degois.publication.firstPage34-54por
degois.publication.issue1por
degois.publication.titleCurrent drug safetypor
dc.peerreviewedyespor
dc.identifier.doi10.2174/157488609787354440-
degois.publication.volume4por
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptInstitute of Interdisciplinary Research-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-1168-2444-
crisitem.author.orcid0000-0001-7014-4614-
crisitem.author.orcid0000-0002-5201-9948-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
Show simple item record

WEB OF SCIENCETM
Citations

73
checked on Oct 2, 2021

Page view(s) 10

975
checked on Oct 8, 2021

Download(s)

297
checked on Oct 8, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.