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Title: Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
Authors: Lemos, Manuel C. 
Fagulha, Ana 
Coutinho, Eduarda 
Gomes, Leonor 
Bastos, Margarida 
Barros, Luisa 
Carrilho, Francisco 
Geraldes, Elizabete 
Regateiro, Fernando J. 
Carvalheiro, Manuela 
Keywords: Vitamin D receptor; Single nucleotide polymorphism; Type 1 diabetes mellitus; Genetic susceptibility
Issue Date: 2008
Citation: Human Immunology. 69:2 (2008) 134-138
Abstract: The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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