Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4674
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dc.contributor.authorResende, Rosa-
dc.contributor.authorMoreira, Paula Isabel-
dc.contributor.authorProença, Teresa-
dc.contributor.authorDeshpande, Atul-
dc.contributor.authorBusciglio, Jorge-
dc.contributor.authorPereira, Cláudia-
dc.contributor.authorOliveira, Catarina Resende-
dc.date.accessioned2008-09-01T14:12:31Z-
dc.date.available2008-09-01T14:12:31Z-
dc.date.issued2008en_US
dc.identifier.citationFree Radical Biology and Medicine. 44:12 (2008) 2051-2057en_US
dc.identifier.urihttp://hdl.handle.net/10316/4674-
dc.description.abstractAlzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence of extracellular senile plaques mainly composed of amyloid-[beta] peptide (A[beta]), intracellular neurofibrillary tangles, and selective synaptic and neuronal loss. AD brains revealed elevated levels of oxidative stress markers which have been implicated in A[beta]-induced toxicity. In the present work we addressed the hypothesis that oxidative stress occurs early in the development of AD and evaluated the extension of the oxidative stress and the levels of antioxidants in an in vivo model of AD, the triple-transgenic mouse, which develops plaques, tangles, and cognitive impairments and thus mimics AD progression in humans. We have shown that in this model, levels of antioxidants, namely, reduced glutathione and vitamin E, are decreased and the extent of lipid peroxidation is increased. We have also observed increased activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. These alterations are evident during the A[beta] oligomerization period, before the appearance of A[beta] plaques and neurofibrillary tangles, supporting the view that oxidative stress occurs early in the development of the disease.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6T38-4S575T6-1/1/a8327ebd74cb7baf97f9aa0ac56dbd9ben_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAlzheimer's diseaseen_US
dc.subject3×Tg-AD mouseen_US
dc.subjectOxidative stressen_US
dc.subjectLipid peroxidationen_US
dc.subjectAntioxidantsen_US
dc.subjectFree radicalsen_US
dc.titleBrain oxidative stress in a triple-transgenic mouse model of Alzheimer diseaseen_US
dc.typearticleen_US
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0002-0504-5756-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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