Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45269
Title: Numerical and analytical study of drug release from a biodegradable viscoelastic platform
Authors: Azhdari, Ebrahim 
Ferreira, José Augusto 
Oliveira, Paula de 
Silva, Pascoal 
Issue Date: 2016
Publisher: Wiley
Issue Date: 2016
Publisher: Wiley
Project: info:eu-repo/grantAgreement/FCT/COMPETE/132981/PT 
Abstract: A mathematical model to simulate drug delivery from a viscoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix that is in contact with water. The entrance of water in the material changes the molecular weight, and bulk erosion can be developed depending on how fast this entrance is and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi-linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscoelastic behavior, the dissolution of the solid drug, and the delivery of the dissolved drug. Numerical simulations illustrating the behavior of the model are included.
URI: http://hdl.handle.net/10316/45269
Other Identifiers: 10.1002/mma.3375
DOI: 10.1002/mma.3375
Rights: embargoedAccess
Appears in Collections:I&D CMUC - Artigos em Revistas Internacionais

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