Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45178
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dc.contributor.authorOliveira, Paulo J.-
dc.contributor.authorMarques, M.Paula M.-
dc.contributor.authorBatista de Carvalho, Luís A.E.-
dc.contributor.authorMoreno, A.J.M.-
dc.date.accessioned2017-12-16T19:10:38Z-
dc.date.available2017-12-16T19:10:38Z-
dc.date.issued2000-
dc.identifier10.1006/bbrc.2000.3374-
dc.identifier.urihttp://hdl.handle.net/10316/45178-
dc.description.abstractCarvedilol (¿1-[carbazolyl-(4)-oxy]-3-[2-methoxyphenoxyethyl)amino]-pro panol-(2) ¿) is a novel compound used in clinical practice for the treatment of congestive heart failure, mild to moderate hypertension, and myocardial infarction. Carvedilol was also shown to protect cardiac mitochondria from oxidative stress events. Because mitochondria are the main suppliers of ATP for cardiac muscle work, a study of the effects of carvedilol in mitochondrial bioenergetics is necessary to fully understand the basis of its protective role in myocardial energetics. In this work we show that carvedilol acts as an uncoupler of oxidative phosphorylation, decreasing mitochondrial electric potential (DeltaPsi) by a weak protonophoretic mechanism. Theoretical studies were carried out to determine the relevance of conformation and proton affinity of the protonable amino side-chain group in the proton-shuttling activity across the inner mitochondrial membrane. BM910228, a hydroxylated metabolite of carvedilol, was also studied for comparison with the parent compound. Implications for the protective role of carvedilol in heart mitochondrial bioenergetics are discussed.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnimalspor
dc.subjectAntioxidantspor
dc.subjectCarbazolespor
dc.subjectElectron Transportpor
dc.subjectMalepor
dc.subjectMembrane Potentialspor
dc.subjectMitochondria, Heartpor
dc.subjectMitochondrial Swellingpor
dc.subjectOxygen Consumptionpor
dc.subjectPropanolaminespor
dc.subjectRatspor
dc.subjectRats, Wistarpor
dc.titleEffects of Carvedilol on Isolated Heart Mitochondria: Evidence for a Protonophoretic Mechanismpor
dc.typearticle-
degois.publication.firstPage82por
degois.publication.lastPage87por
degois.publication.issue1por
degois.publication.titleBiochemical and Biophysical Research Communicationspor
dc.peerreviewedyespor
dc.identifier.doi10.1006/bbrc.2000.3374por
degois.publication.volume276por
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitMolecular Physical-Chemistry-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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