Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45137
DC FieldValueLanguage
dc.contributor.authorCarvalho, L. A. E. Batista de-
dc.contributor.authorMarques, M. Paula M.-
dc.contributor.authorTomkinson, John-
dc.date.accessioned2017-12-15T18:37:50Z-
dc.date.available2017-12-15T18:37:50Z-
dc.date.issued2006-
dc.identifier.urihttp://hdl.handle.net/10316/45137-
dc.description.abstractKetoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Raman and Inelastic Neutron Scattering (INS)]. Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl-carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out-of-plane C-OH bending, and the inter-ring C=O stretching.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnti-Inflammatory Agents, Non-Steroidalpor
dc.subjectElasticitypor
dc.subjectExcipientspor
dc.subjectKetoprofenpor
dc.subjectLactosepor
dc.subjectNeutron Diffractionpor
dc.subjectPovidonepor
dc.subjectSpectrum Analysis, Ramanpor
dc.titleDrug–excipient interactions in ketoprofen: A vibrational spectroscopy studypor
dc.typearticle-
degois.publication.firstPage420por
degois.publication.lastPage424por
degois.publication.issue4por
degois.publication.titleBiopolymerspor
dc.peerreviewedyespor
dc.identifier.doi10.1002/bip.20517-
dc.identifier.doi10.1002/bip.20517por
degois.publication.volume82por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8059-8537-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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