Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45125
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dc.contributor.authorGarrido, Jorge M. P. J.-
dc.contributor.authorMarques, M. Paula M.-
dc.contributor.authorSilva, Artur M. S.-
dc.contributor.authorMacedo, Tice R. A.-
dc.contributor.authorBrett, Ana M. Oliveira-
dc.contributor.authorBorges, Fernanda-
dc.date.accessioned2017-12-15T18:22:53Z-
dc.date.available2017-12-15T18:22:53Z-
dc.date.issued2007-
dc.identifier.urihttp://hdl.handle.net/10316/45125-
dc.description.abstractThe drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine-opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug-drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine-morphine mixture (C-MH), formation of a binary complex was detected; this involved the 3-phenolic group and the heterocyclic oxygen of morphine and the carbonyl oxygen and the methyl protons of cocaine's methyl ester group. NMR studies conducted simultaneously also revealed C-MH binding geometry consistent with theoretical predictions and with electrochemical and vibrational spectroscopy results. These results provide evidence for the occurrence of a cocaine-morphine interaction, both in the solid state and in solution, particularly for the hydrochloride form. A slight interaction, in solution, was also detected by NMR for the cocaine-heroin mixture.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnalgesics, Opioidpor
dc.subjectBinding Sitespor
dc.subjectCocainepor
dc.subjectDrug Interactionspor
dc.subjectElectrochemistrypor
dc.subjectMorphinepor
dc.subjectQuantum Theorypor
dc.subjectSolutionspor
dc.subjectSpectrum Analysispor
dc.titleSpectroscopic and electrochemical studies of cocaine–opioid interactionspor
dc.typearticle-
degois.publication.firstPage1799por
degois.publication.lastPage1808por
degois.publication.issue8por
degois.publication.titleAnalytical and Bioanalytical Chemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1007/s00216-007-1375-z-
dc.identifier.doi10.1007/s00216-007-1375-zpor
degois.publication.volume388por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0001-8981-231X-
crisitem.author.orcid0000-0002-8391-0055-
crisitem.author.orcid0000-0003-2861-8286-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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