Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45096
Title: Inelastic Neutron Scattering Study of PtII Complexes Displaying Anticancer Properties
Authors: Carvalho, Luís A. E. Batista de 
Marques, M. Paula M. 
Martin, Christine 
Parker, Stewart F. 
Tomkinson, John 
Keywords: Antineoplastic Agents; Carboplatin; Cisplatin; Coordination Complexes; Neutron Diffraction; Platinum; Scattering, Small Angle
Issue Date: 2011
Serial title, monograph or event: ChemPhysChem
Volume: 12
Issue: 7
Abstract: The well-known platinum(II) chemotherapeutic drugs cisplatin [cis-(NH(3))(2)PtCl(2)] and carboplatin [Pt(NH(3))(2)C(6)O(4)H(6)], as well as the analogous transplatin [trans-(NH(3))(2)PtCl(2)], were studied by inelastic neutron scattering (INS) spectroscopy, coupled to quantum mechanical methods, and some ancillary work with X-ray diffraction on powders. An assignment of the experimental spectra was carried out based on the calculated INS transition frequencies and intensities (at the DFT level), thereby achieving a good correspondence between the calculated and observed data. Unusually good-quality INS spectra were obtained from about 250 mg, which is the smallest sample of a hydrogenous compound for which a successful INS interpretation has been reported. The knowledge of the local configuration of this kind of complexes is essential for an accurate understanding of their activity, which will pave the way for the rational design of novel third-generation drugs comprising cisplatin- and carboplatin-like moieties.
URI: http://hdl.handle.net/10316/45096
DOI: 10.1002/cphc.201001067
10.1002/cphc.201001067
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
CPC_11_12.pdf336.25 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

21
checked on May 29, 2020

WEB OF SCIENCETM
Citations 5

26
checked on Oct 2, 2021

Page view(s) 20

667
checked on Oct 8, 2021

Download(s)

192
checked on Oct 8, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.