Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45089
DC FieldValueLanguage
dc.contributor.authorSilva, T.M.-
dc.contributor.authorOredsson, S.-
dc.contributor.authorPersson, L.-
dc.contributor.authorWoster, P.-
dc.contributor.authorMarques, M. P. M.-
dc.date.accessioned2017-12-15T17:37:12Z-
dc.date.available2017-12-15T17:37:12Z-
dc.date.issued2012-
dc.identifier.urihttp://hdl.handle.net/10316/45089-
dc.description.abstractA vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAntineoplastic Agentspor
dc.subjectPalladiumpor
dc.subjectPlatinumpor
dc.subjectPlatinum Compoundspor
dc.subjectPolyaminespor
dc.subjectSpectroscopy, Fourier Transform Infraredpor
dc.subjectSpectrum Analysis, Ramanpor
dc.titleNovel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysispor
dc.typearticle-
degois.publication.firstPage1por
degois.publication.lastPage7por
degois.publication.titleJournal of Inorganic Biochemistrypor
dc.peerreviewedyespor
dc.identifier.doi10.1016/j.jinorgbio.2011.11.021-
dc.identifier.doi10.1016/j.jinorgbio.2011.11.021por
degois.publication.volume108por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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