Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/44674
Title: A 3D Model for Mechanistic Control of Drug Release
Authors: Ferreira, José Augusto 
Grassi, M. 
Gudin͂o, Elias 
Oliveira, Paula de 
Issue Date: 2014
Publisher: Society for Industrial and Applied Mathematics (SIAM)
Project: PEst-C/MAT/UI0324/2011 
Serial title, monograph or event: SIAM Journal on Applied Mathematics
Volume: 74
Issue: 3
Abstract: A three-dimensional mathematical model for sorption/desorption by a cylindrical polymeric matrix with dispersed drug is proposed. The model is based on a system of partial differential equations coupled with boundary conditions over a moving boundary. We assume that the penetrant diffuses into a swelling matrix and causes a deformation, which induces a stress-driven diffusion and consequently a non-Fickian mass flux. A physically sound nonlinear dependence between strain and penetrant concentration is considered and introduced in a Boltzmann integral with a kernel computed from a Maxwell--Wiechert model. Numerical simulations show how the mechanistic behavior can have a role in drug delivery design.
URI: http://hdl.handle.net/10316/44674
Other Identifiers: 10.1137/130930674
DOI: 10.1137/130930674
Rights: openAccess
Appears in Collections:I&D CMUC - Artigos em Revistas Internacionais

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