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Title: Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
Authors: Milhazes, Nuno 
Martins, Pedro 
Uriarte, Eugenio 
Garrido, Jorge 
Calheiros, Rita 
Marques, M. Paula M. 
Borges, Fernanda 
Keywords: 3,4-Methylenedioxymethamphetamine; Synthesis; Raman spectroscopy; Voltammetry; Density functional theory calculations
Issue Date: 2007
Citation: Analytica Chimica Acta. 596:2 (2007) 231-241
Abstract: A complete physicochemical characterisation of MDMA and its synthetic precursors MDA, 3,4-methylenedioxybenzaldehyde (piperonal) and 3,4-methylenedioxy-[beta]-methyl-[beta]-nitrostyrene was carried out through voltammetric assays and Raman spectroscopy combined with theoretical (DFT) calculations. The former provided important analytical redox data, concluding that the oxidative mechanism of the N-demethylation of MDMA involves the removal of an electron from the amino-nitrogen atom, leading to the formation of a primary amine and an aldehyde. The vibrational spectroscopic experiments enable to afford a rapid and reliable detection of this type of compounds, since they yield characteristic spectral patterns that lead to an unequivocal identification.
DOI: 10.1016/j.aca.2007.06.027
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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