Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/3799
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dc.contributor.authorFerreira, Lino-
dc.contributor.authorGil, Maria H.-
dc.contributor.authorCabrita, António M. S.-
dc.contributor.authorDordick, Jonathan S.-
dc.date.accessioned2008-08-29T15:26:37Z-
dc.date.available2008-08-29T15:26:37Z-
dc.date.issued2005en_US
dc.identifier.citationBiomaterials. 26:23 (2005) 4707-4716en_US
dc.identifier.urihttp://hdl.handle.net/10316/3799-
dc.description.abstractWe have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 [mu]m depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TWB-4F7Y94V-3/1/0d83788c215a34850e13d6d76d3bba82en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDextranen_US
dc.subjectHydrogelen_US
dc.subjectCross-linkingen_US
dc.subjectBiodegradationen_US
dc.titleBiocatalytic synthesis of highly ordered degradable dextran-based hydrogelsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.biomaterials.2004.11.051-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-8985-9302-
crisitem.author.orcid0000-0001-5165-5849-
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais
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