Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/33718
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dc.contributor.authorFresco, P.-
dc.contributor.authorBorges, F.-
dc.contributor.authorDiniz, C.-
dc.contributor.authorMarques, M. P. M.-
dc.date.accessioned2016-12-20T10:42:32Z-
dc.date.available2016-12-20T10:42:32Z-
dc.date.issued2006-
dc.identifier.urihttp://hdl.handle.net/10316/33718-
dc.description.abstractCancer, one of the major causes of death across the world, has shown to be a largely preventable disease, highly susceptible to modulation by dietary factors. Phenolic compounds, abundant in vegetables and fruits ubiquitous in diet, were described to play an important role as chemopreventive agents. Since conventional therapeutic and surgical approaches have not been able to control the incidence of most cancer types, the development of chemopreventive strategies is an urgent priority in public health. The current diet phenolic intake is often insufficient to protect from mutagens (either exogenous or endogenous), which leads to the need for dietary supplementation as an alternative approach. Research efforts are placing increasing emphasis on identifying the biological mechanisms and in particular the signal transduction pathways related to the chemopreventive activities of these compounds. These effects are believed to occur by the regulation of signaling pathways such as nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) or mitogen-activated protein kinases (MAPK). Dietary polyphenols can exert their effects on these pathways separately or sequentially and in addition the occurrence of crosstalk between these pathways cannot be overlooked. By modulating cell signaling pathways, polyphenols activate cell death signals and induce apoptosis in precancerous or malignant cells resulting in the inhibition of cancer development or progression. However, regulation of cell signaling pathways by dietary polyphenols can also lead to cell proliferation/survival or inflammatory responses due to increased expression of several genes. The present review summarizes the most recent advances providing new insights into the molecular mechanisms underlying the promising anticarcinogenic activity of dietary polyphenols.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectAnticarcinogenic Agentspor
dc.subjectAntioxidantspor
dc.subjectApoptosispor
dc.subjectCell Cyclepor
dc.subjectDietpor
dc.subjectFlavonoidspor
dc.subjectHumanspor
dc.subjectNF-kappa Bpor
dc.subjectPhenolspor
dc.subjectPolyphenolspor
dc.titleNew insights on the anticancer properties of dietary polyphenolspor
dc.typearticle-
degois.publication.firstPage747por
degois.publication.lastPage766por
degois.publication.issue6por
degois.publication.titleMedicinal Research Reviewspor
dc.peerreviewedyespor
dc.identifier.doi10.1002/med.20060-
degois.publication.volume26por
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.orcid0000-0002-8391-0055-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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