Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/28222
DC FieldValueLanguage
dc.contributor.authorMatos, Vítor M. J.-
dc.contributor.authorSantos, Ana Luísa-
dc.date.accessioned2015-02-13T16:06:14Z-
dc.date.accessioned2018-01-10T16:46:00Z-
dc.date.available2015-02-13T16:06:14Z-
dc.date.available2018-01-10T16:46:00Z-
dc.date.issued2015-02-
dc.identifier.issn1472-9792-
dc.identifier.urihttp://hdl.handle.net/10316/28222-
dc.description.abstractThe comparative study of patients’ profiles and outcomes from pulmonary tuberculosis (TB), before and after the discovery of antibiotic therapy, using sanatoria archives is an unexplored approach in paleopathology. Although higher mortality rates are assumed before chemotherapy, scarce information exists regarding the disease’s duration in institutionalized patients and to what extent tuberculous sufferers lived enough to develop skeletal lesions. To fill this gap, 315 clinical files from the former male Sanatorium Carlos Vasconcelos Porto, located in São Brás de Alportel, Portugal, were studied. Two periods of hospitalization were considered: 1931-1944 (n=128, Group 1) and 1955-1961 (n=187, Group 2). The average duration of hospitalization (350.3 days for Group 1 and 371.8 for Group 2) and the crude mortality (18.2% and 11.2%, respectively in Groups 1 and 2) did not differ significantly between groups. However, Cox’s regression revealed significant differences between survival curves, after adjusting for age at admission (14-74 years old), with pre-chemotherapy patients presenting a higher risk of dying during hospitalization (p=0.37, hazard ratio=1.94, IC95%=1.03-3.63). This study also confirms poorer prognoses for pulmonary tuberculosis sufferers hospitalized in sanatoria before antibiotics and reveals that a significant number of patients survived enough time to develop bone lesions.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectPulmonary tuberculosispor
dc.subjectSanatoriapor
dc.subjectMortalitypor
dc.subjectSurvival analysispor
dc.subjectAntibioticspor
dc.subjectPaleopathologypor
dc.titleTrends in mortality from pulmonary tuberculosis before and after antibiotics in the Portuguese sanatorium Carlos Vasconcelos Porto (1918-1991): archival evidence and its paleopathological relevancepor
dc.typearticlepor
degois.publication.titleTuberculosispor
dc.relation.publisherversionhttp://www.journals.elsevier.com/tuberculosispor
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.tube.2015.02.008-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitResearch Centre for Anthropology and Health-
crisitem.author.researchunitResearch Centre for Anthropology and Health-
crisitem.author.orcid0000-0003-2620-7352-
crisitem.author.orcid0000-0001-6073-1532-
Appears in Collections:I&D CIAS - Artigos em Revistas Internacionais
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