Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25581
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dc.contributor.authorMonteiro, João P.-
dc.contributor.authorOliveira, Paulo J.-
dc.contributor.authorJurado, A. S.-
dc.date.accessioned2014-04-23T11:09:55Z-
dc.date.available2014-04-23T11:09:55Z-
dc.date.issued2013-
dc.identifier.urihttp://hdl.handle.net/10316/25581-
dc.description.abstractMitochondria are arbiters in the fragile balance between cell life and death. These organelles present an intricate membrane system, with a peculiar lipid composition and displaying transverse as well as lateral asymmetry. Some lipids are synthesized inside mitochondria, while others have to be imported or acquired in the form of precursors. Here, we review different processes, including external interventions (e.g., diet) and a range of biological events (apoptosis, disease and aging), which may result in alterations of mitochondrial membrane lipid content. Cardiolipin, the mitochondria lipid trademark, whose biosynthetic pathway is highly regulated, will deserve special attention in this review. The modulation of mitochondrial membrane lipid composition, especially by diet, as a therapeutic strategy for the treatment of some pathologies will be also addressed.por
dc.description.sponsorshipWork at the authors laboratory is supported by the Portuguese Foundation for Science and Technology and FEDER/COMPETE (research Grants PTDC-QUI-QUI-101409-2008; PTDC/QUI-BIQ/ 103001/2008 and Pest-C/SAU/LA0001/2013-2014). J.P.M. acknowledges FCT for Ph.D. Grant SFRH/BD/37626/2007.por
dc.language.isoengpor
dc.publisherElsevier Ltd.por
dc.rightsopenAccesspor
dc.subjectMitochondrial membrane lipidspor
dc.subjectCardiolipinpor
dc.subjectApoptosispor
dc.subjectAgingpor
dc.subjectPathologypor
dc.titleMitochondrial membrane lipid remodeling in pathophysiology: A new target for diet and therapeutic interventionspor
dc.typeotherpor
degois.publication.firstPage513por
degois.publication.lastPage528por
degois.publication.issue4por
degois.publication.titleProgress in Lipid Researchpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0163782713000428#por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.plipres.2013.06.002-
degois.publication.volume52por
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCNC.IBILI-
crisitem.author.orcid0000-0001-7095-5337-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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