Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/24854
DC FieldValueLanguage
dc.contributor.authorCarvalho, Filipa S.-
dc.contributor.authorBurgeiro, Ana-
dc.contributor.authorGarcia, Rita-
dc.contributor.authorMoreno, Antonio J.-
dc.contributor.authorCarvalho, Rui A.-
dc.contributor.authorOliveira, Paulo J.-
dc.date.accessioned2014-01-07T16:13:00Z-
dc.date.available2014-01-07T16:13:00Z-
dc.date.issued2013-03-11-
dc.identifier.citationCarvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J. - Doxorubicin-induced cardiotoxicity : from bioenergetic failure and cell death to cardiomyopathy [em linha]. "Medicinal Research Reviews" Vol. 34 : nº 1 (2013), p. 106-135. DOI 10.1002/med.21280.-
dc.identifier.issn1098-1128-
dc.identifier.urihttp://hdl.handle.net/10316/24854-
dc.description.abstractDoxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitochondrial Complex I, resulting in increased oxidative stress. The present review describes and critically discusses what is known about some of the potential mechanisms of DOX-induced cardiotoxicity including mitochondrial oxidative damage and loss of cardiomyocytes. We also discuss alterations of mitochondrial metabolism and the unique characteristics of DOX delayed toxicity, which can also interfere on how the cardiac muscle handles a “second-hit stress.” We also present pharmaceutical and nonpharmaceutical approaches that may decrease DOX cardiac alterations in animal models and humans and discuss the limitations of each strategy.por
dc.language.isoengpor
dc.publisherWiley Periodicals, Inc.por
dc.rightsopenAccesspor
dc.subjectDoxorubicinpor
dc.subjectToxicitypor
dc.subjectMitochondriapor
dc.subjectCardiac metabolismpor
dc.titleDoxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathypor
dc.typearticlepor
degois.publication.firstPage106por
degois.publication.lastPage135por
degois.publication.issue1por
degois.publication.titleMedicinal Research Reviewspor
dc.relation.publisherversionDOI 10.1002/med.21280por
dc.peerreviewedYespor
degois.publication.volume34por
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.orcid0000-0003-3575-7604-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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