Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/24816
DC FieldValueLanguage
dc.contributor.authorDuarte, Sónia-
dc.contributor.authorCarle, Georges-
dc.contributor.authorFaneca, Henrique-
dc.contributor.authorLima, Maria C. Pedroso de-
dc.contributor.authorPierrefite-Carle, Valérie-
dc.date.accessioned2013-12-27T16:44:58Z-
dc.date.available2013-12-27T16:44:58Z-
dc.date.issued2012-11-
dc.identifier.citationDUARTE, Sónia [et al.] - Suicide gene therapy in cancer: Where do we stand now?. "Cancer Letters". ISSN 0304-3835. 324:2 (2012) 160-170por
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10316/24816-
dc.description.abstractSuicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vivo studies, its application to cancer patients has not reached the desirable clinical significance. However, recent reports on pre-clinical cancer models demonstrate the huge potential of this strategy when used in combination with new therapeutic approaches. In this review, we summarize the different suicide gene systems and gene delivery vectors addressed to cancer, with particular emphasis on recently developed systems and associated bystander effects. In addition, we review the different strategies that have been used in combination with suicide gene therapy and provide some insights into the future directions of this approach, particularly towards cancer stem cell eradication.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectSuicide gene therapypor
dc.subjectCancerpor
dc.subjectBystander effectpor
dc.subjectCombined strategiespor
dc.titleSuicide gene therapy in cancer: Where do we stand now?por
dc.typearticlepor
degois.publication.firstPage160por
degois.publication.lastPage170por
degois.publication.issue2por
degois.publication.titleCancer Letterspor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/journal/03043835por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.canlet.2012.05.023-
degois.publication.volume324por
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-1844-5027-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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