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Title: Suicide gene therapy in cancer: Where do we stand now?
Authors: Duarte, Sónia 
Carle, Georges 
Faneca, Henrique 
Lima, Maria C. Pedroso de 
Pierrefite-Carle, Valérie 
Keywords: Suicide gene therapy; Cancer; Bystander effect; Combined strategies
Issue Date: Nov-2012
Publisher: Elsevier
Citation: DUARTE, Sónia [et al.] - Suicide gene therapy in cancer: Where do we stand now?. "Cancer Letters". ISSN 0304-3835. 324:2 (2012) 160-170
Serial title, monograph or event: Cancer Letters
Volume: 324
Issue: 2
Abstract: Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vivo studies, its application to cancer patients has not reached the desirable clinical significance. However, recent reports on pre-clinical cancer models demonstrate the huge potential of this strategy when used in combination with new therapeutic approaches. In this review, we summarize the different suicide gene systems and gene delivery vectors addressed to cancer, with particular emphasis on recently developed systems and associated bystander effects. In addition, we review the different strategies that have been used in combination with suicide gene therapy and provide some insights into the future directions of this approach, particularly towards cancer stem cell eradication.
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2012.05.023
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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