Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/20017
DC FieldValueLanguage
dc.contributor.authorCastro, Ricardo-
dc.contributor.authorRibeiro, João-
dc.contributor.authorMaria, Teresa-
dc.contributor.authorRamos Silva, Manuela-
dc.contributor.authorYuste-Vivas, Consuelo-
dc.contributor.authorCanotilho, João-
dc.contributor.authorEusébio, Ermelinda-
dc.date.accessioned2012-05-18T10:37:09Z-
dc.date.issued2011-10-07-
dc.identifier.urihttp://hdl.handle.net/10316/20017-
dc.description.abstractA screening of naproxen cocrystals with coformers picolinamide, nicotinamide, isonicotinamide, and pyrazinamide is performed by the Kofler contact method and mechanochemistry. The solids obtained by mechanochemistry are characterized by differential scanning calorimetry, DSC, polarized light thermomicroscopy, PLTM, infrared spectroscopy, FTIR, and X-ray powder diffraction, XRPD. No cocrystal could be prepared under the experimental conditions investigated between naproxen and pyrazinamide, which bears two aromatic nitrogen atoms, ortho and meta to the amide group. For the o-, m-, and p-pyridinecarboxamide isomers, regardless of the aromatic nitrogen position, the coformer interacts with naproxen to give rise to new cocrystals: naproxen:picolinamide, naproxen2:nicotinamide, and naproxen:isonicotinamide. A supramolecular acid:aromatic nitrogen heterosynthon is found in all these cocrystals. The structure of the new naproxen:isonicotinamide compound was solved by single-crystal X-ray diffraction, SXD. As nicotinamide has FDA/GRAS status the naproxen:nicotinamide (2:1) cocrystal is of special relevance.por
dc.language.isoengpor
dc.publisherAmerican Chemical Societypor
dc.rightsclosedAccesspor
dc.titleNaproxen co-crystals with pyridinecarboxamide isomerspor
dc.typearticlepor
degois.publication.firstPage5396por
degois.publication.lastPage5404por
degois.publication.titleCrystal Growth Designpor
dc.date.embargoEndDate10000-01-01-
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/cg2009946por
dc.peerreviewedYespor
dc.identifier.doi10.1021/cg2009946-
degois.publication.volume11por
uc.controloAutoridadeSim-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextreserved-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-1263-9034-
crisitem.author.orcid0000-0002-7143-2228-
crisitem.author.orcid0000-0001-9555-8856-
crisitem.author.orcid0000-0001-6045-2330-
crisitem.author.orcid0000-0002-5515-7721-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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