Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/18512
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dc.contributor.authorOliveira, M Teresa-
dc.contributor.authorRego, A Cristina-
dc.contributor.authorMacedo, Tice R-
dc.contributor.authorOliveira, Catarina R-
dc.date.accessioned2012-03-08T18:27:43Z-
dc.date.available2012-03-08T18:27:43Z-
dc.date.issued2012-03-08-
dc.identifier.urihttp://hdl.handle.net/10316/18512-
dc.description.abstractDrugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All the drugs were shown to induce caspase-3 activation, similarly to staurosporine, a classical inducer of apoptotic cell death. Furthermore, like staurosporine, the drugs of abuse induced a decrease in mitochondrial cytochrome c content, suggesting the involvement of the mitochondrial apoptotic pathway.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.titleDrugs of abuse induce apoptotic features in PC12 cells.por
dc.typearticlepor
degois.publication.firstPage667por
degois.publication.lastPage670por
degois.publication.titleAnnals of the New York Academy of Sciencespor
dc.peerreviewedYespor
dc.identifier.doi10.1196/annals.1299.121-
degois.publication.volume1010por
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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