Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/18512
Title: Drugs of abuse induce apoptotic features in PC12 cells.
Authors: Oliveira, M Teresa 
Rego, A Cristina 
Macedo, Tice R 
Oliveira, Catarina R 
Issue Date: 8-Mar-2012
Serial title, monograph or event: Annals of the New York Academy of Sciences
Volume: 1010
Abstract: Drugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All the drugs were shown to induce caspase-3 activation, similarly to staurosporine, a classical inducer of apoptotic cell death. Furthermore, like staurosporine, the drugs of abuse induced a decrease in mitochondrial cytochrome c content, suggesting the involvement of the mitochondrial apoptotic pathway.
URI: http://hdl.handle.net/10316/18512
DOI: 10.1196/annals.1299.121
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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