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Title: Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated by the RNA Binding Protein Pumilio
Authors: Gomes-Santos, Carina S. S. 
Braks, Joanna 
Prudêncio, Miguel 
Carret, Céline 
Gomes, Ana Rita 
Pain, Arnab 
Feltwell, Theresa 
Khan, Shahid 
Waters, Andrew 
Janse, Chris 
Mair, Gunnar R. 
Mota, Maria M. 
Issue Date: 19-May-2011
Publisher: Public Library of Science
Citation: GOMES-SANTOS, Carina S. S. [et al.] - Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated by the RNA Binding Protein Pumilio. "PLoS Pathogens" [em linha]. Vol. 7, nº 5 (2011) e1002046. [Consult. Dia Mês Ano]. Disponível em WWW:<>. ISSN 1553-7366
Project: info:eu-repo/grantAgreement/EC/FP7/242095 
Serial title, monograph or event: PLoS Pathogens
Volume: 7
Issue: 5
Abstract: Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2) sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism.
ISSN: 1553-7366
DOI: 10.1371/journal.ppat.1002046
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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