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|Title:||Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated by the RNA Binding Protein Pumilio||Authors:||Gomes-Santos, Carina S. S.
Gomes, Ana Rita
Mair, Gunnar R.
Mota, Maria M.
|Issue Date:||19-May-2011||Publisher:||Public Library of Science||Citation:||GOMES-SANTOS, Carina S. S. [et al.] - Transition of Plasmodium Sporozoites into Liver Stage- Like Forms Is Regulated by the RNA Binding Protein Pumilio. "PLoS Pathogens" [em linha]. Vol. 7, nº 5 (2011) e1002046. [Consult. Dia Mês Ano]. Disponível em WWW:<http://hdl.handle.net/10316/15539>. ISSN 1553-7366||Project:||info:eu-repo/grantAgreement/EC/FP7/242095||Serial title, monograph or event:||PLoS Pathogens||Volume:||7||Issue:||5||Abstract:||Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key mRNAs. In malaria parasites (Plasmodium spp.), the development of round, non-motile and replicating exo-erythrocytic liver stage forms from slender, motile and cell-cycle arrested sporozoites is believed to depend on environmental changes experienced during the transmission of the parasite from the mosquito vector to the vertebrate host. Here we identify a Plasmodium member of the RNA binding protein family PUF as a key regulator of this transformation. In the absence of Pumilio-2 (Puf2) sporozoites initiate EEF development inside mosquito salivary glands independently of the normal transmission-associated environmental cues. Puf2- sporozoites exhibit genome-wide transcriptional changes that result in loss of gliding motility, cell traversal ability and reduction in infectivity, and, moreover, trigger metamorphosis typical of early Plasmodium intra-hepatic development. These data demonstrate that Puf2 is a key player in regulating sporozoite developmental control, and imply that transformation of salivary gland-resident sporozoites into liver stage-like parasites is regulated by a post-transcriptional mechanism.||URI:||http://hdl.handle.net/10316/15539||ISSN:||1553-7366||DOI:||10.1371/journal.ppat.1002046||Rights:||openAccess|
|Appears in Collections:||I&D CNC - Artigos em Revistas Internacionais|
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