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Credit Name
Cunha-Oliveira, Teresa
 
Full Name
Oliveira, Maria Teresa Martins da Cunha
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
 
Email
teresa.oliveira@uc-biotech.pt
 
 
 
Scopus Author ID
 
Researcher ID
 
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Status
UC Researcher
 

Publications
(All)

Results 1-52 of 52 (Search time: 0.001 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
22013Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondriaCunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. articleopenAccess
32007Adaptation to oxidative stress in the chronic effects of cocaine and amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
41-Sep-2017Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicityFerreira, André ; Cunha-Oliveira, Teresa ; Simões, Rui F ; Carvalho, Filipa S ; Burgeiro, Ana ; Nordgren, Kendra ; Wallace, Kendall B ; Oliveira, Paulo J articleopenAccess
52015Analysis of pro-apoptotic protein trafficking to and from mitochondriaVega-Naredo, Ignacio ; Cunha-Oliveira, Teresa ; Serafim, Teresa L ; Sardao, Vilma A ; Oliveira, Paulo J articleopenAccess
62009BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neuronsAlmeida, S. ; Laço, M. ; Cunha-Oliveira, T. ; Oliveira, C. R. ; Rego, A. C. articleopenAccess
7Nov-2017Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblastsCoelho, Ana R ; Martins, Tatiana R ; Couto, Renata ; Deus, Cláudia ; Pereira, Cláudia V ; Simões, Rui F ; Rizvanov, Albert A ; Silva, Filomena ; Cunha-Oliveira, Teresa ; Oliveira, Paulo J ; Serafim, Teresa L articleopenAccess
8Sep-2011Bioenergetic dysfunction in Huntington's disease human cybridsFerreira, I Luisa ; Cunha-Oliveira, Teresa ; Nascimento, Maria V ; Ribeiro, Márcio ; Proença, M Teresa ; Januário, Cristina ; Oliveira, Catarina R ; Rego, A Cristina articleopenAccess
92008Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. articleopenAccess
10Feb-2012Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathwaysCunha-Oliveira, Teresa ; Ferreira, Ildete L ; Rego, A Cristina bookPartopenAccess
112006Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, Teresa ; Rego, A. Cristina ; Morgadinho, Maria Teresa ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
122005Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxideCunha-Oliveira, T. ; Rego, A. C. ; Morgadinho, M. T. ; Sarmento, A. ; Macedo, T. ; Oliveira, C. R. conferenceObjectopenAccess
13Dec-2013Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transitionBernardo, Telma C. ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Holy, Jon ; Krasutsky, Dmytro ; Kolomitsyna, Oksana ; Krasutsky, Pavel ; Moreno, António M. ; Oliveira, Paulo J. articleopenAccess
142013Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transitionBernardo, Telma C. ; Cunha-Oliveira, Teresa ; Serafim, Teresa L. ; Holy, Jon ; Krasutsky, Dmytro ; Kolomitsyna, Oksana ; Krasutsky, Pavel ; Moreno, A. J. M. ; Oliveira, Paulo J. articleopenAccess
15Sep-2012Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in micePereira, Frederico ; Cunha-Oliveira, Teresa ; Viana, Sofia ; Travassos, Ana Sofia ; Nunes, Sara ; Silva, Carlos ; Prediger, Rui ; Rego, Ana Cristina ; Ali, Syed ; Fontes Ribeiro, Carlos Alberto articleclosedAccess
1625-Nov-2019Doxorubicin persistently rewires cardiac circadian homeostasis in miceFerreira, Luciana L ; Cervantes, Marlene; Froufe, Hugo J C; Egas, Conceição ; Cunha-Oliveira, Teresa ; Sassone-Corsi, Paolo; Oliveira, Paulo JembargoedAccess
172018Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytesCunha-Oliveira, Teresa ; Ferreira, Luciana L ; Coelho, Ana Raquel ; Deus, Cláudia M ; Oliveira, Paulo J articleopenAccess
182009Dysregulation of CREB Activation and Histone Acetylation in 3-Nitropropionic Acid-Treated Cortical Neurons: Prevention by BDNF and NGFAlmeida, Sandra ; Cunha-Oliveira, Teresa ; Laço, Mário ; Oliveira, Catarina R. ; Rego, A. Cristina articleopenAccess
199-Mar-2012Efeito crónico da heroína e do peróxido de hidrogénio em células PC12Cunha-Oliveira, Teresa ; Rego, A Cristina ; Morgadinho, M Teresa ; Macedo, Tice R ; Oliveira, Catarina R articleopenAccess
203-Dec-2020Effects of Extended Passaging on the BEAS-2B Cell Line, an in vitro Model of Human Lung Epithelium Established for the Study of Lung CarcinogenesisSobral, Margarida Conceição MoreiramasterThesisembargoedAccess
2121-Sep-2018Experimental enhancement of cellular OXPHOS reliance for mitochondrial health assessments - Development and characterization of a rapid and efficient method to induce OXPHOS in skin fibroblasts, for the assessment of mitochondiral toxicity and protection.Costa, Cláudio Figueiredo masterThesisopenAccess
228-Mar-2012Expression of NR1/NR2B N-Methyl-d-Aspartate Receptors Enhances Heroin Toxicity in HEK293 CellsDomingues, António ; Cunha-Oliveira, Teresa ; Laço, Mário LN ; Macedo, Tice ; Oliveira, Catarina R ; Rego, A Cristina articleopenAccess
2315-Nov-2012Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cellsRibeiro, Márcio ; Rosenstock, Tatiana ; Cunha-Oliveira, Teresa ; Ferreira, Ildete ; Oliveira, Catarina R. ; Rego, Ana Cristina articleopenAccess
242005Heroin-induced degeneration of cortical neurons involves mitochondria-dependent apoptosisCunha-Oliveira, T. ; Rego, A.C. ; Macedo, T. ; Oliveira, C.R. articleopenAccess
25Aug-2018Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cellsAbreu, Patrícia L ; Cunha-Oliveira, Teresa ; Ferreira, Leonardo M R ; Urbano, Ana M. articleopenAccess
268-Mar-2017Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's DiseaseNaia, Luana ; Cunha-Oliveira, Teresa ; Rodrigues, Joana ; Rosenstock, Tatiana R ; Oliveira, Ana ; Ribeiro, Márcio ; Carmo, Catarina ; Oliveira-Sousa, Sofia I ; Duarte, Ana I ; Hayden, Michael R ; Rego, A Cristina articleopenAccess
273-Oct-2019Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic StressFerreira, Leonardo M R ; Cunha-Oliveira, Teresa ; Sobral, Margarida C. ; Abreu, Patrícia L ; Alpoim, Maria Carmen; Urbano, Ana MopenAccess
289-Dec-2020Impact of Rebaudioside A in cancer cell metabolism: Potential as a safe chemotherapeutic adjuvantAfonso, Gonçalo José MartinsmasterThesisopenAccess
2918-Sep-2019Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's DiseaseValdinocci, Dario; Simões, Rui F. ; Kovarova, Jaromira ; Cunha-Oliveira, Teresa ; Neuzil, Jiri ; Pountney, Dean LopenAccess
30Aug-2016Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicitySilva, Ana Marta ; Barbosa, Inês A. ; Seabra, Cátia ; Beltrão, Nuno ; Santos, Raquel ; Vega-Naredo, Ignacio ; Oliveira, Paulo ; Cunha-Oliveira, Teresa articleopenAccess
31Mar-2016Ketogenic diets: from cancer to mitochondrial diseases and beyondBranco, Ana F. ; Ferreira, André ; Simões, Rui F. ; Magalhães-Novais, Sílvia ; Zehowski, Cheryl ; Cope, Elisabeth ; Silva, Ana Marta ; Pereira, Daniela ; Sardão, Vilma A. ; Cunha-Oliveira, Teresa articleopenAccess
322013Medical Toxicology of Drugs of AbuseCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Carvalho, Félix ; Oliveira, Catarina R. bookPartopenAccess
331-Jul-2018Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative CapacityPereira, Susana P ; Deus, Cláudia M ; Serafim, Teresa L ; Cunha-Oliveira, Teresa ; Oliveira, Paulo J articleopenAccess
3416-Sep-2019Mitochondria-based screening of drug neurotoxicity in differentiated SH-SY5Y cellsFerrão, Rafaela Margarida CuramasterThesisembargoedAccess
35Dec-2014Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblastsMoreira, Ana C ; Branco, Ana F ; Sampaio, Susana F ; Cunha-Oliveira, Teresa ; Martins, Tatiana R ; Holy, Jon ; Oliveira, Paulo J ; Sardão, Vilma A articleopenAccess
361-May-2013Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondriaCunha-Oliveira, Teresa ; Silva, Lisbeth ; Silva, Ana Maria ; Moreno, António J. ; Oliveira, Catarina R. ; Santos, Maria S. articleopenAccess
372006Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamineCunha-Oliveira, T. ; Rego, A. C. ; Cardoso, S. M. ; Borges, F. ; Swerdlow, R. ; Macedo, T. ; Oliveira, C. R. articleopenAccess
3820-Nov-2019Mitochondrial remodeling in human skin fibroblasts from sporadic PD male patients uncovers metabolic and mitochondrial bioenergetics defectsDeus, Cláudia M ; Pereira, Susana P; Cunha-Oliveira, Teresa ; Pereira, Francisco B. ; Raimundo, Nuno Filipe Viegas das Neves ; Oliveira, Paulo JembargoedAccess
392011Molecular interaction between cocaine and opioids. Implications on Speedball's toxicityCunha-Oliveira, T. ; Silva, L. ; Silva, A. M. ; Santos, M. S. ; Garrido, J. ; Borges, F. ; Rego, A. C. ; Oliveira, C. R. conferenceObjectopenAccess
407-Nov-2007Neuronal dysfunction induced by drugs of abuseOliveira, Maria Teresa Martins da Cunha doctoralThesisopenAccess
412012Neurotoxicity of cocaineCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. bookPartopenAccess
428-Mar-2012Neurotoxicity of heroin-cocaine combinations in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina R articleopenAccess
4328-Aug-2014Oxidative Stress and Drugs of Abuse: An UpdateCunha-Oliveira, Teresa ; Rego, A. Cristina ; Oliveira, Catarina R. articleopenAccess
445-Feb-2019Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer CellsBajzikova, Martina ; Kovarova, Jaromira ; Coelho, Ana R ; Boukalova, Stepana ; Oh, Sehyun ; Rohlenova, Katerina ; Svec, David ; Hubackova, Sona ; Endaya, Berwini ; Judasova, Kristyna ; Bezawork-Geleta, Ayenachew ; Kluckova, Katarina ; Chatre, Laurent ; Zobalova, Renata ; Novakova, Anna ; Vanova, Katerina ; Ezrova, Zuzana ; Maghzal, Ghassan J ; Magalhaes Novais, Silvia ; Olsinova, Marie ; Krobova, Linda ; An, Yong Jin ; Davidova, Eliska ; Nahacka, Zuzana ; Sobol, Margarita ; Cunha-Oliveira, Teresa ; Sandoval-Acuña, Cristian ; Strnad, Hynek ; Zhang, Tongchuan ; Huynh, Thanh ; Serafim, Teresa L ; Hozak, Pavel ; Sardao, Vilma A ; Koopman, Werner J H ; Ricchetti, Miria ; Oliveira, Paulo J ; Kolar, Frantisek ; Kubista, Mikael ; Truksa, Jaroslav ; Dvorakova-Hortova, Katerina ; Pacak, Karel ; Gurlich, Robert ; Stocker, Roland ; Zhou, Yaoqi ; Berridge, Michael V ; Park, Sunghyouk ; Dong, Lanfeng ; Rohlena, Jakub ; Neuzil, Jiri articleembargoedAccess
45Sep-2013Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
461-Nov-2012Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abusePerfeito, Rita ; Cunha-Oliveira, Teresa ; Rego, Ana Cristina articleopenAccess
472017Role of Mitochondria on the Neurological Effects of CocainePereira, S.P. ; Cunha-Oliveira, T. articleopenAccess
48Jan-2015Role of mtDNA-related mitoepigenetic phenomena in cancerFerreira, André ; Serafim, Teresa L ; Sardão, Vilma A ; Cunha-Oliveira, Teresa articleopenAccess
49Feb-2019Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblastsFerreira, Luciana L ; Cunha-Oliveira, Teresa ; Veloso, Caroline D ; Costa, Cláudio F ; Wallace, Kendall B ; Oliveira, Paulo J articleembargoedAccess
502007Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neuronsCunha-Oliveira, Teresa ; Rego, A. Cristina ; Garrido, Jorge ; Borges, Fernanda ; Macedo, Tice ; Oliveira, Catarina Resende articleopenAccess
51Oct-2006Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells: A Putative Structure−Toxicity RelationshipMilhazes, Nuno ; Cunha-Oliveira, Teresa ; Martins, Pedro ; Garrido, Jorge ; Oliveira, Catarina ; Rego, A. Cristina ; Borges, Fernanda articleopenAccess
522014β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?Branco, Ana F ; Moreira, Ana C ; Cunha-Oliveira, Teresa ; Couto, Renata ; Sardao, Vilma A ; Rizvanov, Albert A ; Palotas, Andras ; Oliveira, Paulo J articleopenAccess